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导致流产的内分泌因素有哪些?What does the endocrine factor that brings about abortion have?

  母体内分泌失调会导致流产,如黄体功能不全,多囊卵巢等,具体分布如下:

  Maternal endocrine disorders will lead to abortion, such as luteal dysfunction, polycystic ovary, etc., the specific distribution is as follows:

  (1)黄体功能不全占23%~60%,黄体期孕酮低于15ng/ml引起妊娠蜕膜反应不良,2~3个周期黄体功能检测显示不足,方可纳入诊断,黄体功能不全影响孕卵着床。

  (1) luteal dysfunction accounted for 23% ~ 60%, and luteal progesterone in luteal phase was lower than 15ng/ml, resulting in adverse reaction to the decidual membrane of pregnancy. Luteal dysfunction could only be included in the diagnosis if luteal function was not detected in 2 ~ 3 cycles. Luteal dysfunction affected egg implantation.

  (2)多囊卵巢综合征高浓度的促黄体生成素,高雄激素和高胰岛素血症降低了卵子质量和子宫内膜容受性,容易导致流产发生。多囊卵巢若合并子宫纵隔,影响胎儿生长发育。

  (2) the high concentration of luteinizing hormone, high androgen and hyperinsulinemia in polycystic ovary syndrome (pcos) reduces the quality of eggs and endometrial receptivity, which may easily lead to abortion. If polycystic ovary is amalgamated with uterine mediastinum, affect fetal growth and development.

  (3)高泌乳素血症黄体细胞存在泌乳素受体,高泌乳素抑制颗粒细胞黄素化及类固醇激素,导致黄体功能不全和卵子质量下降。

  (3) there are prolactin receptors in luteal cells of hyperprolactinemia, which inhibit the lutein of granulosa cells and steroid hormones, leading to luteal dysfunction and decreased egg quality.

  (4)甲状腺疾病甲状腺功能低下与反复发生的自然流产相关。

  (4) thyroid disease hypothyroidism is associated with recurrent spontaneous abortions.

  (5)糖尿病亚临床或控制满意的糖尿病不会导致流产,未经控制的胰岛素依赖型糖尿病自然流产率增加。

  (5) subclinical or well-controlled diabetes mellitus will not lead to abortion, and the rate of spontaneous abortion of uncontrolled insulin-dependent diabetes mellitus will increase.

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