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导致流产的胎儿染色体因素有哪些?What does the fetal chromosome factor that causes abortion have?

  专家指出:胚胎或胎儿染色体异常是早期流产最常见的原因,约有50%-60%是由“胚胎”染色体异常所致。胚胎染色体异常发生的主要原因有抗胚胎抗体阳性(大于1:64)、宫内环境异常,如纵隔,肌瘤、息肉和内分泌异常等;其次才是孕期接触电离辐射、化学物品、微生物感染和遗传等。

  Experts point out: embryo or fetal chromosome abnormality is the most common cause of early abortion, about 50%-60% is caused by "embryo" chromosome abnormality. The main reasons for the occurrence of fetal chromosome abnormality are the positive anti-embryonic antibody (greater than 1:64) and the abnormal intrauterine environment, such as mediastinum, fibroids, polyps and endocrine abnormalities. Exposure to ionizing radiation, chemicals, microbial infections, and genetics during pregnancy are secondary.

  值得注意的是:染色体异常导致早期流产,是指胚胎染色体异常,而不是指夫妇染色体异常,99.99%的胚胎染色体异常,其夫妇的染色体是正常的;而夫妇有一方染色体异常,胚胎并不一定有异常。这个原因只有胎停育时取胚做染色体培养才能知道。

  It is worth noting that chromosomal abnormalities leading to early abortion refer to chromosomal abnormalities in embryos, rather than chromosomal abnormalities in couples, which are normal in 99.99% of embryos. If a couple has one abnormal chromosome, the embryo does not necessarily have one. The reason for this can only be known when embryos are taken for chromosome culture during fetal instillation.

  而常见的夫妇染色体异常不会导致习惯性流产,夫妇染色体异常一般都是携带遗传型,即轻度染色体异常,如平衡易位、倒位[46,XY,t(5,12)]等,遗传信息并不少,只是染色体片段发生位移,这样的人外表和生殖腺正常,也不会导致流产,充其量出生的后代染色体与上代一样而已。

  And a couple of common chromosomal abnormalities will not lead to habitual abortion, and chromosomal abnormalities are usually carry genetic type, namely the mild chromosomal abnormalities, such as balanced translocation, inversion [46, XY, t (5, 12)], such as the genetic information and a lot of, just chromosome fragment displacement occurs, such people and gonads appearance is normal, also won't lead to miscarriage, birth offspring chromosomes and made as at best.

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